Brain Cancer Clinical Trials

Showing 181-200 of 1,242 trials

Carmustine Wafer in Combination With Retifanlimab and Radiation With/Without Temozolomide in Subjects With Glioblastoma

NCT05083754

The purpose of the study is to evaluate the safety and survival of carmustine wafers and radiation and retifanlimab with or without temozolomide (TMZ) in newly-diagnosed adult subjects with glioblastoma multiform after carmustine wafer placement.

Glioblastoma Multiforme

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins50 participantsStarted Aug 2022

Baltimore, Maryland, United States

RECRUITINGPhase 2

Trial of Glioblastoma Immunotherapy Advancement With Nivolumab and Relatlimab

NCT06816927

GIANT is an open-label, multi-center, randomized, perioperative (neoadjuvant followed by adjuvant), phase 2 trial with a safety lead-in phase to investigate the feasibility, safety and tolerability, and establish the biological activity of nivolumab with or without relatlimab in patients with isocitrate dehydrogenase (IDH) wildtype newly diagnosed glioblastoma (ndGBM).

Newly Diagnosed Glioblastoma

Duke University92 participantsStarted Nov 2025

Durham, North Carolina, United States

Carmustine Wafer in Combination With Retifanlimab and Radiation With/Without Temozolomide in Subjects With Glioblastoma

Trial of Glioblastoma Immunotherapy Advancement With Nivolumab and Relatlimab

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