Brain Cancer Clinical Trials in Massachusetts

Showing 41-60 of 154 trials

Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma

NCT01063114

There are two types of external radiation treatments (proton beam and photon beam). As part of the participant's treatment, they will receive radiation to the entire central nervous system (CNS); this is known as craniospinal irradiation (CSI). In the past, photon radiation therapy has been used for CSI. In this study we will be examining the effects of proton beam radiation therapy. Studies have suggested that this kind of radiation can cause less damage to normal tissue than photon radiation therapy. The physical characteristics of proton beam radiation let the doctor safely deliver the amount of radiation delivered to the tumor that is normally delivered through standard therapy but spare more normal tissue in the process.

Brain TumorMedulloblastomaPineoblastoma

Massachusetts General Hospital90 participantsStarted Apr 2010

Boston, Massachusetts, United States • Houston, Texas, United States

COMPLETEDEARLY Phase 126 miles

Vemurafenib in Children With Recurrent/Refractory BRAF Gene V600E (BRAFV600E)-Mutant Gliomas

NCT01748149

This is a multicenter, safety and pharmacokinetic trial to determine the MTD and/or select a recommended phase 2 dose (RP2D) of vemurafenib in children with recurrent or refractory gliomas containing the BRAFV600E or BRAF Ins T mutation.

Pediatric Recurrent/Refractory BRAFV600E-mutant Gliomas

University of California, San Francisco40 participantsStarted Apr 2014

Los Angeles, California, United States • Los Angeles, California, United States • Oakland, California, United States +18 more locations

Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma

Vemurafenib in Children With Recurrent/Refractory BRAF Gene V600E (BRAFV600E)-Mutant Gliomas

Brain Cancer Trials in Other Cities

89Zr-girentuximab for PET Imaging of CAIX Positive Solid Tumors

VB-111 in Surgically Accessible Recurrent/Progressive GBM

Study of Ad-RTS-hIL-12 + Veledimex in Combination With Cemiplimab in Subjects With Recurrent or Progressive Glioblastoma

A Study of Ad-RTS-hIL-12 With Veledimex in Subjects With Glioblastoma or Malignant Glioma

REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma

Safety, Pharmacokinetics and Efficacy of Paxalisib (GDC-0084) in Newly-diagnosed Glioblastoma

Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial)

Feasibility of the LUM Imaging System for Detection of Cancer to the Brain

Adavosertib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma

Psychological Intervention For Brain Tumor Caregivers

Brain Tumor Intraoperative Ultrasound Database

Psychological Intervention for Caregivers of Patients With Malignant Gliomas

Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma

9-ING-41 in Pediatric Patients With Refractory Malignancies.

A Study to Determine How BI 907828 (Brigimadlin) is Taken up in the Tumor (Phase 0) and to Determine the Highest Dose of BI 907828 (Brigimadlin) That Could be Tolerated (Phase 1a) in Combination With Radiation Therapy in People With a Brain Tumor Called Glioblastoma

Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

A Phase III Trial of With Marizomib in Patients With Newly Diagnosed Glioblastoma

Oral AMXT 1501 Dicaprate in Combination With IV DFMO

Other Conditions in Massachusetts