Asthma Clinical Trials

Showing 1261-1280 of 3,705 trials

Clearance Of Mucus In Stents (COMIS)

NCT01370278

The goal of this clinical research study is to compare the effects of sodium bicarbonate to normal saline when used for clearing mucus blockage in patients with airway stents.

Lung NeoplasmsRespiratory FailurePneumonia+5 more

M.D. Anderson Cancer Center43 participantsStarted Jun 2011

Houston, Texas, United States

COMPLETEDPhase 3

COVID-19 Prevention and Treatment in Cancer; a Sequential Multiple Assignment Randomised Trial;

NCT04534725

A multi-centre Australian trial with four arms aims to evaluate several different immune modulating drugs for prevention and treatment of COVID-19 specifically in the cancer population. ARM 1 is evaluating the effect of interferon-alpha (vs placebo) on the incidence of COVID-19 infection in cancer patients with no COVID-19 infection or no known COVID-19 positive contacts. ARM 2 is evaluating the effect of interferon-alpha (vs placebo) on the incidence of COVID-19 infection in cancer patients with confirmed exposure to COVID-19 virus. ARM 3 is evaluating the effect of Selinexor (vs placebo) on the incidence of COVID-19 infection in cancer patients with moderate COVID-19 infection. ARM 4 is evaluating the effect of Lenzilumab (vs placebo) on the treatment of COVID-19 infection in cancer patients with severe COVID-19 infection. Participants may become eligible and transition to different arms and treatments if they become exposed to COVID-19 or are hospitalised with an active moderate/severe COVID-19 infection. It is hoped this research will provide insight into the best practice for prevention and treatment of COVID-19 in cancer patients as emerging standard of care measures are not always suitable to this especially vulnerable population.

CancerCovid19Respiratory Viral Infection

Peter MacCallum Cancer Centre, Australia441 participantsStarted Dec 2020

Westmead, New South Wales, Australia • Fitzroy, Victoria, Australia • Melbourne, Victoria, Australia +2 more locations

Clearance Of Mucus In Stents (COMIS)

COVID-19 Prevention and Treatment in Cancer; a Sequential Multiple Assignment Randomised Trial;

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