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Browse 3,705 clinical trials for asthma. Find studies that match your criteria and connect with research centers.
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NCT05209009
VIDO has developed a vaccine called COVAC-2. The COVAC-2 study vaccine contains a portion of the SARS-CoV-2 spike protein, called S1. The spike protein is the part of the virus that is responsible for attaching to the surface of host cells. COVAC-2 contains a SWE adjuvant. An adjuvant is a compound that is added to a vaccine to help the vaccine produce a better immune response. The SWE adjuvant is similar to another adjuvant, MF59, that is found in influenza vaccines and MF59 containing vaccines have been given to millions of people around the world. The vaccine is expected to stimulate the body to make antibodies against the S1 protein. The antibodies will recognize the viral spike protein if the body is exposed to the virus and prevent severe COVID-19 illness. In animal studies, the immune response generated by the COVAC-2 vaccine was able to protect the vaccinated animals against a severe SARS-CoV-2 infection. This is a Phase 2, placebo-controlled, observer-blind, age-stratified randomized, multicentre study to test the safety and immunogenicity of a dose level of the COVAC-2 vaccine (25 µg protein) administered twice (4 weeks apart) in generally healthy adults 18+ years of age. Up to 300 participants will be enrolled. For an individual participant, the duration of study will be approximately 12 months from the first vaccination (Day 0).
NCT06396182
Low levels of physical activity and sedentary lifestyle have become a major public health problem contributing to the prevalence of many chronic diseases and reduced life expectancy worldwide, and also increase the risk of heart disease, stroke, hypertension, type 2 diabetes, dementia, depression, excessive weight gain, and breast and colon cancer. Physical activity improves functional health and quality of life. (Iva Sklempe Kokic et al., 2019). In Middle East, Insufficient physical activity and sedentary behavior are key risk factors for obesity and other diseases leading to premature mortality. Regular physical activity can improve self-esteem, cognitive performance, and academic achievement in young people. (Sonia Chaabane et al., 2020). University students, due to the time spent in classes, studying or in front of computers, form part of the population most at risk of adopting sedentary behavior. Different studies have shown that the transition to university studies is usually associated to a decrease in physical activity and an increase in sedentary behavior as a result of lifestyle changes, as well as psychosocial factors. (Cotton et al., 2016). Exercise is often perceived as boring and hard, thereby causing adults and students shy away from physical activity -related behaviors after long days of work and/or school. Instead, individuals are more interested in leisure activities, such as video games, Thus, the combination of video games and engaging in physical activity (e.g., virtual reality -integrated exercise) may trigger their interest and improve their physical activity behavior. (Jiali Qian et al., 2020). So, this trial aim to find if the virtual reality exercise as a new modality will make sedentary physical student more interest to adherent to exercise than conventional aerobic training so makes them more physically active which will enhance their academic performance and endurance.