Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

Age ≥ 18
ECOG Performance Status of ≤ 2
Ability to review and signed informed consent
Histologically confirmed, newly diagnosed invasive breast cancer
Lymph node metastases (either histologically confirmed or radiographic evidence of lymph node metastases).
Planned to undergo SOC NAC prior to surgical resection as outlined in section 4.1

Pregnancy or lactation.
Patients who cannot undergo PET/MRI scanning because of:
* devices or implants that are not MRI safe
* hypersensitivity or known allergy to gadolinium-based contrast agents
* physical fitness not allowing scanning in prone for 30 minutes
* weight limits (450 lb. weight limit)
Severe kidney disfunction (estimated GFR \< 30 ml/min/1.73 m2) (CKD-EPI (2021))
Imaging features suspicious for concomitant in-situ cancer (LCIS/DCIS), such as nonbiopsied groups of microcalcifications
Distant metastases (contraindication for NAC)

A Study of 68Ga-FAPI Breast PET/MRI Scans in People With Breast Cancer