This parallel-group randomized controlled trial used a pretest-posttest design to evaluate the effects of the ACTIVE-Care Integrated Physical Activity-Based Supportive Care Program on cancer-related fatigue, hope, and psychological resilience in adolescents with acute lymphoblastic leukemia (ALL).
Seventy adolescents aged 13-16 years were randomly assigned to the intervention group or the control group, with 35 participants in each group.
The intervention group received 12 supervised sessions delivered twice weekly over six weeks. The program integrated individualized physical activity with supportive care components addressing fatigue and energy management, goal setting, self-monitoring, positive feedback, coping, problem-solving, and social support.
The control group received usual care provided by the treating institution, without the ACTIVE-Care program or any additional study-specific intervention.
Cancer-related fatigue was assessed using the Assessment Scale for Fatigue in Pediatric Oncology Patients Aged 13-18 Years. Hope was assessed using the Children's Hope Scale (CHS), and psychological resilience was assessed using the Child and Youth Resilience Measure-12 (CYRM-12). Assessments were conducted at baseline, within one week before the intervention, and immediately after the six-week intervention.
