Anatomy Impact on RT Breast Cancer

To date, at IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" (IRST) there is no system of objective criteria that allows the planner to determine the optimal planning and treatment technique based on the patient's characteristics. This is a prospective observational study (non interventional study). Therefore no changes will be performed on clinical practice already in use. Any decision about drug administration is made by the physician based on his clinical judgment in the context of clinical practice, independently from the decision to include the patient in this study. Patients participating in the trial will not be subjected to any procedure that falls outside the clinical practice; in the same way, clinical variables that will be collected for the study are those that are commonly collected by physician in daily clinical practice. A total of at least 30 patients will be included in the study. Dose prescription will be 40.05 Gy (Gray) in 15 fractions. For each patient, 3 RT treatment plans will be simulated: 3D-CRT, IMRT (S\&S), and hybrid technique (3D-CRT+IMRT). A total of 90 plans will be available. The best treatment technique will be chosen based on scoring provided by at least 3 expert clinicians. The primal plan choice will be the one with higher total rate, evaluated as a sum of 3 single rates. The study duration will be approximately 30 months.