Diagnosis of RA meeting 2010 ACR/EULAR classification criteria
Seropositive or seronegative RA eligible
Any baseline disease activity (remission/low/moderate/high) to minimize selection bias
Owns a compatible smartphone (iOS/Android) and is willing/able to use the Oura app
Willing to wear Oura Ring during sleep throughout study participation (target adherence ≥5 valid nights/week)
Willing to complete weekly remote assessments and attend baseline and three monthly routine follow-up visits
Able to read and write English language
Able to provide written informed consent
You may not be if
Atrial fibrillation or other clinically significant arrhythmias expected to invalidate HRV interpretation
Implanted pacemaker/defibrillator where HRV measurements are unreliable
Severe autonomic dysfunction likely to interfere with HRV interpretation (e.g., advanced diabetic autonomic neuropathy), per investigator judgment
Recent major cardiovascular event within 6 months (e.g., myocardial infarction) or uncontrolled heart failure (NYHA class III-IV), per investigator judgment
Current use of beta-blockers (excluded due to known autonomic/HRV effects)
Pregnancy or planned pregnancy during the study period
Inability to wear the ring reliably (e.g., occupational restrictions or hand deformity preventing wear)
Participation in another interventional clinical trial likely to confound outcomes
Clareo Health | HRV Variation in Rheumatoid Arthritis
