Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
King's College London
With
South London and Maudsley NHS Foundation Trust
Age
18–65
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Have used cannabis at least once in the past
Willing and able to provide written informed consent
Willing to provide blood samples for screening purposes
Agrees to use highly effective methods of contraception for the duration of the study and for 3 months after the final study visit (see Contraception below)
Be able to understand the information sheet
You may not be if
Having a past or present major mental illness
Having a past or present major physical illness (e.g. respiratory or heart condition)
Not having a normal ECG reading at screening visit
Having screening blood tests outside normal ranges, determined to be clinically significant
Having a past or present substance use disorder
Having ever been treated with an anti-psychotic or anti-depressant medication
Having a first degree relative (parent or sibling) with psychotic illness
Currently taking psychotropic medication
Having a positive urine drug screen (any drug) at any of the study visits (baseline and experimental sessions)
Having self-reported use of alcohol within 24h of an experimental visit or a positive alcohol breath test
Being pregnant or planning pregnancy or lactating in women
Discovery of significant abnormality during physical examination at screening visit
Is using cannabis (defined as days in which cannabis is used recreationally) more often than once per week on average over the last 12 months.
Smoking more than 4 cigarettes or vapes per week.
Drinking more than 4 units (100ml) of coffee per day.
Any past use of synthetic cannabinoids
Having a score of 5 or more on the Fagerstrom Nicotine Dependence Questionnaire
Having a BMI classified as obese or underweight (below 18 or over 30)
Having participated in a drug study within the last 30 days
Having a known sensitivity or allergy towards cannabis or Lorazepam
Clareo Health | An Investigation of Mechanisms That Underly Paranoia in Behaviour and Brain That Can Inform Clinical Diagnoses That Include Paranoid Symptoms.
