Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan No.1 Hospital
Wuhan Puren Hospital
Xiangyang Central Hospital
Xinyang Central Hospital
Age
18–60
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Age 18-60 years, male or female.
2. Diagnosis of vestibular migraine according to the Bárány Society criteria.
3. ≥4 episodes of characteristic vestibular symptoms in the past year, each of moderate to severe intensity and lasting \>2 hours (without intervention).
4. Signed informed consent obtained from the participant.
You may not be if
1. Presence of other disorders causing acute vestibular symptoms (e.g., Ménière's disease, otitis media).
2. Coexisting non-vertiginous dizziness (e.g., dizziness due to panic disorder), unless the patient can clearly distinguish these episodes from vestibular-migraine attacks.
3. Severe hepatic dysfunction (ALT and/or AST \>3× upper limit of normal) or renal impairment (creatinine clearance \<30 mL/min).
4. Severe cardiovascular or cerebrovascular disease.
5. Alcohol abuse or substance abuse.
6. Known pregnancy or lactation, or a positive pregnancy test prior to randomization.
7. Contraindication or hypersensitivity to any medications used in the study.
8. Initiation or dose adjustment of any preventive migraine therapy within 3 months prior to study drug administration.
9. Use of any other anti-vertigo or analgesic medication within 6 hours before study drug administration.
10. Participation in another interventional clinical study that could affect outcome assessment.
11. Any other condition that, in the investigator's judgment, makes the participant unsuitable for the study or poses significant risk.
