Men and women with stable mild to moderate chronic kidney disease \[CKD\] (stage G3a-b (estimated glomerular filtration rate \[eGFR\] 30-\<60mL/min/1.73 m²) and albuminuria stages A1-3 (UACR from \< 30mg/g to ≥ 300 mg/g))
45-75 years old at screening
Overweight/obesity (Body Mass Index \[BMI\] ≥25 and ≤40 kg/m²)
Meet at least one of the following conditions:
(i) Systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg, or use of antihypertensive agents (ii) Triglycerides ≥150 mg/dL, LDL cholesterol ≥160 mg/dL, HDL cholesterol ≤40 mg/dL in men or ≤50 mg/dL in women, or use of lipid-modifying medication (iii) Prediabetes or type 2 diabetes according to the American Diabetes Association (ADA) Standards, or use of glucose-lowering medication.
You may not be if
Inability to give written informed consent
CKD caused by polycystic kidney disease, chronic pyelonephritis, and renal dysplasia
CKD on renal replacement therapy (hemodialysis, peritoneal dialysis, and kidney transplant recipients)
Acute exacerbation of CKD, whether due to extrarenal causes (decompensated heart failure, infectious disease or sepsis, surgical intervention) or due to an outbreak of underlying glomerular or systemic renal pathology, with changes in treatment in the last 2 months.
Nut allergy
Alcoholism (\>50 g/day) or drug abuse
Treatment with immunosuppressant drugs or cytotoxic agents
Any other medical condition that interferes with the completion of the protocol (pregnancy/breastfeeding, history of inflammatory bowel disease, liver failure, cancer or active neoplasms, psychiatric problems)
