National Institute of Neurological Disorders and Stroke (NINDS)
Age
18–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Symptomatic participants with ALS must have an ALS Functional Rating Scale-Revised (ALSFRS-R) score of 47/48 or less at the time of recruitment.
Asymptomatic/presymptomatic participants must have a pathogenic C9orf72 expansion of at least 25 repeats or a similar genetic abnormality known to be associated with ALS.
Healthy control participants must have no clinically identifiable neurological deficits based on medical history and screening. -
You may not be if
Any safety concern or contraindication to MRI based on MRI safety screening.
Healthy control participants who do not pass the neurological screening.
Pregnancy.
Metal implants above the waist, including cardiac pacemakers or brain, neck, cervical, or thoracic implants.
Neurocognitive impairment.
Inability or unwillingness to provide informed consent.
Younger than 18 years of age.
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