Symptomatic epiphora (unilateral or bilateral) with tearing requiring eyelid wiping or dabbing at least 2 times per day (Munk score ≥2)
Epiphora attributed to functional/idiopathic, gustatory, environmental, or lacrimal outflow (e.g., nasolacrimal duct obstruction, punctal stenosis) etiology
Visual acuity of 20/200 or better in at least one eye (with habitual correction or pinhole)
Willing and able to self-administer eye drops nightly for 7 days in each of two treatment periods and attend all study visits
Prior use of topical atropine permitted if at least 10 days have elapsed since the last dose
You may not be if
Clinically significant dry eye disease, or tearing judged to be a reflex response to ocular surface disease, blepharitis, or other ocular surface irritation
Regular use of artificial tears, ocular lubricants, or dry eye medications, or unwillingness to stop them during the study
Active or recent (within 30 days) ocular infection, or active dacryocystitis
Current use of ophthalmic anticholinergic agents (unless stopped at least 10 days before Visit 1)
Hypersensitivity to atropine, other anticholinergics, or any component of the formulation
Angle-closure glaucoma or narrow anterior chamber angles
Pregnancy or breastfeeding
Participation in another interventional study within 30 days
Any condition or medication that, in the investigator's judgment, would interfere with study assessments or subject safety
