ERICA-02 Study : Impact of Physical Exercise on the Tumor Immune Microenvironment in Patients Treated With Neoadjuvant Chemoimmunotherapy for Non-small Cell Lung Cancer
Patients with locally advanced, resectable non-small cell lung cancer (NSCLC), stage IIA (≥ 4 cm) to IIIA according to the TNM classification (American Joint Committee on Cancer, 9th edition)
PD-L1 positive
ECOG performance status of 0 or 1 at diagnosis
Sufficient tumor material for the analyses planned by the study Note: The amount of available material must be validated by the coordinating center before patient enrollment
With measurable disease according to RECIST version 1.1 criteria
Recently diagnosed and eligible for neoadjuvant chemotherapy-immunotherapy, as decided by the multidisciplinary tumor board (MTB)
Having obtained medical certification of fitness to engage in physical activity, issued by the referring oncologist or the principal investigator
Willing and deemed likely to comply with the intervention and visit schedule and follow-up examinations throughout the duration of the study
Able to understand, read, and speak French
Affiliated with a social security scheme
Having been informed about the study and having signed an informed consent form
You may not be if
Activating EGFR mutations or ALK translocations, as well as those who have received prior chemotherapy, immunotherapy, or radiotherapy for their current lung cancer
History of cancer within the last 5 years
Uncontrolled cardiovascular disease, including heart failure, unstable coronary artery disease, severe arrhythmias, or uncontrolled hypertension that could limit participation in physical activity, according to the investigator
Uncontrolled type 2 diabetes despite appropriate treatment
Severe limiting pulmonary disease such as GOLD stage IV chronic obstructive pulmonary disease, or severe restrictive lung disease
Major neuropsychiatric disorders that could hinder participation in the program (e.g., dementia, Alzheimer's disease, advanced Parkinson's disease)
Severe physical disability or any other medical condition that contraindicates participation in an exercise program • Concurrent participation in another physical activity study
Pregnant woman
Person deprived of liberty by judicial or administrative decision, or adult protected by law
Clareo Health | ERICA-02 Study : Impact of Physical Exercise on the Tumor Immune Microenvironment in Patients Treated With Neoadjuvant Chemoimmunotherapy for Non-small Cell Lung Cancer
