Age

60–any

Sex

FEMALE

Healthy volunteers

Accepted

use of hormone therapy containing synthetic estrogen
MRI contraindications (e.g., irremovable ferrous metal in body, claustrophobia)
history of neurological disorder (including mild cognitive impairment) or moderate to severe traumatic brain injury
use of antipsychotic, opiate, or mood stabilizer (i.e., lithium) medication
history of blood clots/deep vein thrombosis, prior stroke or TIA, uncontrolled hypertension
history of migraine with aura
severe liver disease
history of breast, endometrial, or ovarian cancer
smoking \>10 cigarettes/day

Acute Effects of Estradiol Administration on Brain Function During Fear Learning