Finding studies
Finding studies
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Clinical Trials Information Medical Monitor
CONTACT
Study Director Medical Monitor
CONTACT
Lead
Leal Therapeutics, Inc
After providing informed consent, eligible participants will be asked to visit the study site 3 times and stay overnight for 35 nights (up to 49 nights if up to 14 days of antipsychotic washout is applicable). Procedures will include: * A review of medical history and medications * Physical exams, including a neurologic (nervous system) assessment * Electrocardiograms (a measure of the heart's electrical activity) * Blood and urine collection * Psychiatric assessments including the Mini International Neuropsychiatric Exam (MINI), the Brief Assessment of Cognition in Schizophrenia (BACS), and the Positive and Negative Syndrome Scale (PANSS) * Overall assessment of status via the Clinical Global Impression Scale - Severity (CGI-S) * Assessment of extrapyramidal symptoms (EPS) as assessed by the Modified Simpson-Angus Scale (M-SAS), the Abnormal Involuntary Movement Scale (AIMS) and the Barnes Akathisia Rating scale (BARS) * Assessment of suicidality risk via the Columbia Suicidality Severity Rating Scale (C-SSRS) * Quantitative electroencephalography (qEEG) assessments * Ophthalmologic examinations * Administration of the study drug (or placebo) by mouth
Age
18–55
Sex
ALL
Healthy volunteers
Not accepted