Ability and willingness to provide written informed consent.
Normotensive individuals or individuals with newly diagnosed, previously untreated primary hypertension, classified according to the European Society of Hypertension (ESH) guidelines.
Ability to comply with all study procedures.
You may not be if
Secondary hypertension.
Previous treatment with antihypertensive medication.
History of cardiovascular disease (except newly diagnosed primary hypertension in the hypertensive group).
Diabetes mellitus.
Chronic kidney disease.
Cerebrovascular disease.
Peripheral arterial disease.
Acute or chronic inflammatory or infectious disease.
Active malignancy.
Pregnancy or breastfeeding.
Current use of oral contraceptives, hormone replacement therapy, or medications known to affect endothelial function.
Inability or unwillingness to provide informed consent.
