A Study to Learn How Different Amounts of the Study Medicine Called PF-08103402 Are Tolerated and Act in the Body in Healthy Adults or Adults With Mild To-moderate Asthma

Age

18–65

Sex

ALL

Healthy volunteers

Accepted

1. Are males or females who can no longer have children,
2. Are 18 to 65 years old,
3. Have a body mass index (BMI) of 16 to 32 kilograms per meter squared and a total body weight of more than 50 kilograms (110 pounds).
For Part A (Optional group or cohort 3: Japanese participants only):
1. A total body weight of more than 45 kg (100 pounds).
2. Have 4 biological Japanese grandparents who were born in Japan.
For Part E only:
1. Adults with a documented doctor's-diagnosis history of asthma for at least 12 months before entering the study.
2. Have a body mass index (BMI) of 16 to 35 kilograms per meter squared and a total body weight of more than 50 kilograms (110 pounds).

1. Evidence or history of clinically significant medical conditions.
2. History of human immunodeficiency virus (HIV) infection, hepatitis B, or hepatitis C; positive testing for HIV, hepatitis B surface antigen (HBsAg), or hepatitis C antibody (HCVAb).
3. History of alcohol abuse or binge drinking and/or any other illicit drug use or dependence within 6 months of Screening.
4. Participation in studies of other investigational products (drug or vaccine) at any time during their participation in this study.
5. Any history of parasitic infection requiring treatment within 28 days prior to screening.
6. Positive tuberculosis infection test result.
7. Part C only: Evidence or history of conditions interfering with the ability to taste.
8. Part D only: History of irregular bowel movements.
9. Part E only: Evidence of lung disease(s) other than asthma.
10. Part E only: Asthma exacerbation within 3 months prior to screening.
11. Part F only: History of acute narrow-angle glaucoma, untreated open-angle glaucoma, sleep apnea, respiratory insufficiency, myasthenia gravis or adverse reaction to midazolam or other benzodiazepines.