Second Xiangya Hospital of Central South University
Guangzhou Mental Hospital
First Affiliated Hospital of Kunming Medical University
Brain Hospital Hunan Province
Hunan Mental Hospital
The Affiliated Hospital of Hangzhou Normal University
Zhejiang Provincial Tongde Hospital
Shanghai Mental Health Center
Age
18–60
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1: a primary diagnosis of bipolar II disorder in accordance with DSM-V criteria, in a current major depressive episode;
2: scoring ≥17 on the 17-item Hamilton Rating Scale for Depression (HAMD-17)
3: scoring \<12 on the Young Mania Rating Scale (YMRS)
4: medication-free (≥4 weeks without psychotropics)
5: with rhythm disturbance, scoring \>26 on the Biological Rhythm Interview for Neuropsychiatry (BRIAN)
6: Understand written language and be able to conduct questionnaire survey
7: 18 to 60 years old, gender is not limited
8: the patient voluntarily participates, signs a written informed consent form, is willing to participate in the study and undergo evaluation
9: Han Chinese
10: Right-handedness
You may not be if
1: diseases that may significantly increase research risks or interfere with the evaluation of results
2: patients with rapid-cycling bipolar disorder (with \>4 episodes within the past year);
3: any psychiatric or organic mental disorder, bipolar I disorder (BD I), current alcohol or drug dependence, borderline or antisocial personality disorder
4: patients currently receiving any psychological treatment or melatonin treatment intervention
5: patients with active suicidal ideation, HAMD-17 item 3 score ≥3
6: pregnant
7: patients with metal objects in the body (pacemaker, cochlear implant, implanted teeth, braces, metal foreign bodies, cardiac stent/intravascular coil, orthopedic steel plate, etc.) and other MRI examination contraindications (claustrophobia or inability to cooperate with the examination).
Clareo Health | Efficacy and Mechanism of IPSRT for Bipolar II Disorder
