Have presence of index knee pain for more than 12 weeks at screening
Have an x-ray supporting diagnosis of osteoarthritis according to the American College of Rheumatology with a Kellgren-Lawrence grade 2 to 4 radiographic classification of index knee
Have a body mass index ≤40 kilograms per meter squared (kg/m²) (inclusive)
Have stable glycemic control as indicated by a glycated hemoglobin (HbA1c) less than or equal to 10 at time of screening
You may not be if
Are pregnant or breastfeeding
Have had a surgical procedure or therapeutic injection in the affected knee within 3 months prior to screening
Have presence of surgical hardware or other foreign body in the index knee
Have ongoing complex regional pain syndrome or other concurrent medical condition that could interfere with the evaluation of pain in the index knee.
Have had any joint replacement of the lower extremity, such as hip, knee or ankle, in the 6 months prior to screening
Have an abnormal blood pressure (BP) (systolic BP greater than 140 millimeters mercury (\>140 mm Hg) and diastolic BP\>90 mm Hg) at screening
Have history or current clinically significant cardiac disease, including arrhythmia, aortic aneurysm, heart failure, current electrolyte abnormalities, or any other conditions that could predispose to arrhythmia in the judgement of the investigator
Clareo Health | A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain
