Clareo Health | Effect of Vasopressin Versus Norepinephrine on Post-operative Mean Pulmonary Arterial Pressure Following Pulmonary Endarterectomy Surgery,
Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Fondation Hôpital Saint-Joseph
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age ≥18 years;
Patient scheduled for pulmonary endarterectomy surgery;
In women of childbearing potential: negative serum pregnancy test and use of adequate contraception;
Affiliation to the French social care service;
Patient able to understand and sign a written informed consent form.
You may not be if
Emergency surgery;
Mesenteric ischemia and/or acute coronary syndrome within the month preceding the intervention;
Patients with documented mesenteric artery stenosis;
Impossibility to insert the pulmonary artery catheter (anatomical or technical issue);
Preoperative administration of norepinephrine and/or inotropic drugs (dobutamine, isoproterenol, epinephrine) or patients assisted by veno-venous or veno-arterial ECMO before surgery;
Known allergy to the active substance vasopressin or to any of its excipients;
Concomitant coronary bypass procedure or other combined surgery (i.e. valve replacement);
mPAP\<25 mmHg on preoperative right heart catheterization;
Patient with preoperative natremia below 130 mol/L;
Patient participating to another interventional clinical trial;
For females only: documented pregnancy or lactation;
Patient under tutorship, curatorship or legal protection;
