This study will be conducted in 2 parts:
* Part A: Single dose (SD), dose-ranging part in adults with mild to moderate hypertension.
* Part B: SD in adults with mild to moderate hypertension.
Age
18–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Is an adult participant with a mean seated office systolic blood pressure (SBP) of at least 130 mmHg and no more than than 170 mmHg
Either not taking antihypertensive medication or on stable therapy with up to 2 antihypertensive medications
Is an adult participant with a mean seated office SBP of at least 140 mmHg and no more than 170 mmHg
Has discontinued all prior antihypertensive medication other than a calcium channel blocker (CCB) and/or thiazide/thiazide-like diuretic (if taking) for at least 3 weeks
You may not be if
Has known secondary hypertension or serum potassium more than 5 mmol/L
Has an estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73m\^2
