A Study of Cardiac Magnetic Resonance Imaging (CMR) for Evaluating Catheter-Associated Right Atrial Clot in People With Cancer

Inclusion Criteria

• •Documentation of Disease
• •o Patients must have pathologically confirmed systemic cancer of any types and stages (solid tumors or hematologic malignancies) at the time of CMR which will be used to evaluate the presence or absence of cardiac mass and additional tissue characterization for confirmation of RATHR.
• •Definition of Disease \[or Measurable Disease\]
• •* Cardiac mass (CMASS) will be initially localized on cine-CMR, on which it is defined via established criteria as a discrete tissue prominence independent from normal anatomic structures, quantified based on size (area, cross-sectional linear dimensions)
• •* CMASS will be further categorized by type (CNEO or CTHR) based on CMR tissue characterization: CNEO and CTHR can be differentiated based on presence of contrast enhancement via the reference standard of LGE-CMR using established criteria previously validated by our group and others.
• •CTHR is defined as discrete mass(es) with avascular tissue properties (enhancement absent).
• •CTHR will be further subgrouped into RATHR after confirmation of its location and in relation to CVC.
• •CNEO is defined as discrete mass(es) with vascular tissue properties (enhancement present),
• •CNEO can be further sub-typed based on visually scored magnitude of enhancement (diffusely hyper-enhancing, mixed, predominantly hypo-enhancing) in accordance with established methods previously used by our group.
• •Required Organ Function:
• •o Adequate renal function defined as follows:
• •Creatinine clearance (CrCL) of ≥30 mL/min by the Cockcroft-Gault formula (Note: For agents for which renal excretion is not a major route of clearance and for which renal toxicity is not an issue, the threshold for creatinine clearance should be ≥30 mL/min.):
• •CrCl (mL/min) = \[140 - age (years)\] x weight (kg) 72 \* creatinine (mg / dL)
• •Allergies
• •No history of allergic reaction to the gadolinium contrast agent or compounds of similar chemical or biologic composition
• •Subjects in RATHR+ group must meet the following criteria:
• •* Adult cancer patients (stage I-IV) who are greater than 18 years of age
• •* Presence of indwelling central venous catheter (Mediport, PICC, Hickman, pheresis cath, etc) with a minimal duration of 7 days prior to CMR
• •* Presence of RATHR based on established CMR criteria (i.e. absence of enhancement on LGE-CMR)