Personalized Therapy of Long-term Low FODMAP in IBS Treatment: Role of Mobile Application and "Microbiota-gut-brain" Axis

Exclusion Criteria

• •Inability to understand the study procedures or provide written informed consent.
• •Currently pregnant.
• •History of Inflammatory Bowel Disease (IBD).
• •Active infection within the past 90 days.
• •History of thyroid disease.
• •Major psychiatric disorders, including patients with significant anxiety or depression currently requiring treatment with anti-anxiety or anti-depressant medications.
• •History of epilepsy.
• •History of stroke, cerebral hemorrhage, or other central nervous system diseases.
• •Significant renal, hepatic, or major cardiovascular diseases.
• •Malignant diseases (cancer).
• •Type 2 diabetes.
• •Other chronic pain conditions.
• •History of abdominal surgery (excluding cholecystectomy or appendectomy) or any history of brain surgery.
• •Appendectomy or cholecystectomy performed within the past year.
• •Currently participating in other clinical trials.
• •Use of antibiotics or analgesics within 90 days prior to enrollment.
• •Newly initiated use of probiotics or prebiotics within 90 days prior to enrollment.
• •Current use of antipsychotic medications, antidiarrheal agents, probiotics, or analgesics.