National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age 18 years or older
Loss of ≥15% of initial body weight using anti-obesity medication
Discontinued anti-obesity medication within the past 4 weeks or planning to discontinue prior to randomization
≤3 kg weight regain within the past 3 months
Willing and able to participate in a 6-month behavioral intervention, including a 10-week foundational program
Willing to complete study assessments at baseline, 3 months, and 6 months, including required in-person visits
Medical clearance for participation in moderate physical activity, dietary modification, and mind-based practices
Access to reliable internet for participation in virtual sessions and remote data collection
English fluency sufficient to complete study procedures
Able to provide informed consent
You may not be if
Medical conditions that would preclude safe participation in physical activity, dietary changes, or mind-based practices (e.g., unstable cardiovascular disease, uncontrolled hypertension, severe orthopedic limitations, or seizure disorders not medically managed)
Active psychiatric conditions that would interfere with participation or safety (e.g., untreated major depression, active substance use disorder, or psychosis)
Pregnancy, breastfeeding, or plans to become pregnant during the study period
Current participation in another structured weight loss or weight maintenance program
Continued use of anti-obesity medication after randomization
Plans to initiate medications or treatments that may significantly affect body weight during the study period
Inability to attend required study visits or participate in virtual sessions and remote data collection
Any condition that, in the opinion of the investigators, would compromise participant safety or study integrity
