Hypoxia and Hemodilution Testing in Healthy Adult Volunteers

Exclusion Criteria

• •1. BMI above 30.
• •2. History of heart, lung, kidney, or liver disease.
• •3. Diagnosis of asthma, sleep apnea, or use of CPAP.
• •4. Diabetes mellitus.
• •5. Clotting disorders.
• •6. Hemoglobinopathy or history of anemia (ctHb \<12 g/dL for men, \<11 g/dL for women, COHb \>2%).
• •7. Any serious systemic illness.
• •8. Current smoker.
• •9. Injury or abnormality at sensor sites interfering with measurements.
• •10. History of fainting or vasovagal response.
• •11. Sensitivity to local anesthesia.
• •12. Diagnosis of Raynaud's disease.
• •13. Unacceptable collateral circulation (Allen's test).
• •14. Pregnant, lactating, or attempting to become pregnant.
• •15. Unable or unwilling to provide informed consent or comply with study procedures.
• •16. Any other condition deemed unsuitable by the investigator.