Pulmonary hypertension (PH) is a severe complication of chronic lung diseases (CLDs) that significantly worsens patient outcomes. Although extracellular matrix (ECM) remodeling is central to PH pathogenesis, the basement membrane (BM)-a specialized ECM-remains understudied. The BM's dynamic role in lung tissue organization and signaling may provide insight into disease progression and phenotypic heterogeneity.
The investigators hypothesize that BM remodeling and the release of its bioactive components generate a measurable molecular fingerprint reflecting PH onset and progression in CLD. This study aims to prove the concept of using BM-derived fingerprints for disease detection and patient stratification.
Age
18–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Patients undergoing lung transplantation with COPD or PF, with or without associated PH and PAH.
\- Outpatient cohort with COPD or PF, with or without associated PH or PAH.
You may not be if
Presence of other lung diseases
Signs of infection, such as pneumonia, pulmonary tuberculosis, or pleural effusions.
Clareo Health | Collagen Fingerprinting for Stratification of Pulmonary Hypertension (PH) Patients
