Fangyi Wang, Bachelor

CONTACT

Lead Sponsor

Qilu Pharmaceutical Co., Ltd.

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

No

•1. Female or male，age 18 to 75.
•2. Body mass index (BMI) ≥ 22 kg/m² and ≤ 35 kg/m² at screening.
•3. HbA1c of 7.0-10.5 %.
•4. Diagnosed with type 2 diabetes mellitus at least 90 days prior to day of screening.
•5. Stable daily dose of metformin (at least 1500 mg or maximum tolerated dose≥1000 mg/day) at least 90 days prior to the day of screening.

•1. Family or personal history of Multiple Endocrine Neoplasia Type 2 or Medullary Thyroid Carcinoma.
•2. History of pancreatitis (acute or chronic).
•3. History of major surgical procedures involving the stomach potentially affecting absorption of trial product (e.g. subtotal and total gastrectomy, sleeve gastrectomy, gastric bypass surgery).
•4. Subjects presently classified as being in New York Heart Association Class IV.
•5. Planned coronary, carotid or peripheral artery revascularisation known on the day of screening.
•6. Renal impairment defined as Estimated Glomerular Filtration Rate below 60 mL/min/1.73 m\\\^2 as per Chronic Kidney Disease Epidemiology Collaboration formula (CKD-EPI).