This study used randomized experimental and control groups in its design. Participants were women with active sexual lives who visited a Family Health Center in Istanbul for three months. Sample size was determined using power analysis. Women in the experimental group participated in a nursing education program titled "HPV and its Effects on Women's Health." Written informed consent was obtained from the participants. A pre-test was administered to all participants. Following the baseline assessment, participants in the experimental group participated in a nurse-led education program prepared by the researcher. The program focused on HPV transmission, prevention methods, vaccination, screening, and its effects on women's health. Participants in the control group did not receive any educational intervention at this stage. One month after the completion of the training, post-tests were administered to both groups. The assessment tools used were as follows: Women's sociodemographic characteristics, participation in health screenings, and HPV-related characteristics were recorded on an Information Form. Women's knowledge level about HPV was measured using the HPV Knowledge Scale. The scale consisted of 33 items and 2 sub-dimensions. The first sub-dimension of the scale is scored between 0 and 16. Higher scores indicate a higher level of general knowledge about HPV. The second subdimension measures the level of knowledge about the HPV vaccination program. The total score obtainable from this subdimension ranges from 0 to 6. Higher scores indicate a higher level of knowledge about HPV vaccination.