Safety and Efficacy of High-Channel Implanted BCI for Motor Function Improvement in Tetraplegia Patients

Exclusion Criteria

• •Females who are pregnant
• •History of drug abuse or alcoholism
• •Diseases that limit limb mobility: fractures (progressive/deformity-causing fractures), hip dysplasia and other diseases causing limited hip mobility, diabetic foot, severe osteoporosis, limb joint contracture deformity, spasticity, and hospitalization due to autonomic dysreflexia in the past 3 months
• •Neurological diseases/injuries: traumatic brain injury, epilepsy, neurodegenerative diseases or neuropathies, severe anxiety or depression, and suicidal ideation
• •Surgical contraindications: infectious diseases; unstable angina pectoris, severe arrhythmia, and other heart diseases; immune system diseases and major organ diseases; coagulation disorders and bleeding tendencies; ankylosing spondylitis; malignant tumors; spinal instability and spinal stenosis
• •BMI ≥ 30.0 kg/m²
• •Patients with depressive disorder (17-item Hamilton Depression Rating Scale \[HAMD\] score \> 17)
• •Patients unable to comply with the study protocol