Effect of Low-dose Pregabalin Retard (82.5 mg) Versus Standard-dose Pregabalin Retard (165 mg) on Postoperative Pain and Opioid Consumption After Elective Laparoscopic Abdominal Surgery

Exclusion Criteria

• •Known allergy or intolerance to pregabalin, gabapentinoids, or study medications
• •Chronic opioid use (daily use \>30 mg oral morphine equivalent for \>2 weeks preoperatively)
• •Regular use of gabapentin or pregabalin within 30 days
• •Severe renal impairment (eGFR \< 30 mL/min/1.73 m²) or on dialysis
• •Severe hepatic impairment (Child-Pugh C)
• •Uncontrolled epilepsy or other major neurological disorder
• •Severe psychiatric disease, alcohol or substance abuse
• •Pregnancy or breastfeeding
• •Planned postoperative ICU admission for reasons other than routine overnight monitoring
• •Conversion to open abdominal surgery (these patients will be analyzed in sensitivity or excluded, predefined in analysis plan)