Microbiome-Focused Food Supplement for Evaporative Dry Eye Due to Meibomian Gland Dysfunction

Exclusion Criteria

• •1. Sjögren syndrome or other active systemic autoimmune disease with significant ocular involvement (investigator judgment).
• •2. Active ocular infection, acute blepharitis flare, or active allergic conjunctivitis requiring escalation of therapy.
• •3. Ocular surgery (including cataract) or significant ocular trauma within 6 months prior to the Screening Visit.
• •4. Previous LASIK or any prior corneal surgery at any time.
• •5. Use of topical cyclosporine, lifitegrast, or topical ocular corticosteroids within 6-8 weeks prior to baseline, or planned initiation during the treatment period.
• •6. Punctal plugs within 3 months prior to baseline or planned during the study.
• •7. Use of glaucoma medications or history of glaucoma filtering surgery.
• •8. Contact lens use within 30 days prior to baseline or planned use during the study.
• •9. Systemic isotretinoin within 6 months prior to baseline.
• •10. Systemic antibiotic use within 8 weeks prior to baseline.
• •11. Eyelid abnormalities affecting lid function (e.g., lagophthalmos, blepharospasm, ectropion, entropion, severe trichiasis).
• •12. Active thyroid eye disease (thyroid orbitopathy) or clinically significant ocular surface exposure secondary to thyroid dysfunction.
• •13. Extensive ocular surface scarring or conditions compromising ocular surface integrity, including Stevens-Johnson syndrome, prior chemical burn, recurrent corneal erosions, persistent epithelial defects, or prior severe ocular trauma.
• •14. Known hypersensitivity to study product ingredients.
• •15. Any medical or ocular condition that, in the investigator's opinion, would compromise patient safety or study integrity.
• •16. Pregnancy or breastfeeding (if applicable) or planning pregnancy during the intervention period.
• •17. Gastrointestinal diseases known to significantly affect digestion, absorption, or intestinal physiology, including but not limited to inflammatory bowel disease, celiac disease, or a history of major gastrointestinal surgery
• •18. Individuals following restrictive or specialized dietary patterns, including ketogenic, vegan, or similar diets