PK/PD Target Attainment of Ceftriaxone for the Prevention of Early Ventilator-associated Pneumonia in Neurologically Injured Patients

Exclusion Criteria

• •Acute brain injury related to tumoral or infectious process
• •Antibiotic therapy administered before acute brain injury for an other pathology
• •Patients with a risk of multiresistance bacteria contamination (stay in a risk area in the past 3 months, antibiotic therapy with fluoroquinolone or betalctamine in the past 3 months, hospitalization in last month before admission, documented contaminationwith multiresistance bacteria, immunodepression)
• •Patients with hish risk of death in the first 48 hours
• •Patients with a beta-lactams reported allergy