Forty Women with asthma with PCOS will be enrolled to be catogrized to Group I or group II. Group I will enroll twenty females with PCOS and asthma who will apply forty minutes walking on treadmill three times per week. Also Group I will follow low calorie diet and daily metformin for 12 weeks. Group II will will enroll twenty females with PCOS and asthma who will follow low calorie diet and daily metformin for 12 weeks