Pre-Symptomatic Detection of Impending Decompensation in Heart Failure Through Voice Data

Heart failure decompensation is often detected too late by conventional symptom and weight monitoring, leaving insufficient time to intervene. Invasive alternatives such as implantable pulmonary artery pressure monitors are effective but require surgical implantation. Voice-based digital biomarkers offer a promising non-invasive approach, as fluid overload may produce detectable changes in vocal features. Patients begin voice recordings during hospitalization while still volume overloaded. At home, patients record daily using standardized and variable text content. The voice-based algorithm extracts biomechanical vocal features and calculates a risk score. Healthcare providers access a dashboard showing symptom-based notifications and may adjust therapy at their discretion. Voice-derived risk scores are withheld during the study and analyzed retrospectively. Study visits occur at months 3 and 6 (in-clinic) and month 1 (telephone). Blood samples are collected at baseline, month 3, and month 6 for analysis of traditional (NT-proBNP, creatinine) and novel biomarkers. Usability and quality of life are assessed via questionnaires distributed throughout the study period.