Lead Sponsor

Marina Castel Sánchez

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Age ≥ 18 years.
•Clinical diagnosis of Multiple Sclerosis with EDSS score between 2.0 and 6.5, with upper-limb involvement.
•Ability to maintain independent sitting and to stand with or without assistive devices.
•Upper-limb functional capacity between 11 and 54 points on the ARAT, indicating limited to substantial impairment.
•Cognitive ability to understand and follow simple instructions, demonstrated by a Mini-Mental State Examination score ≥ 23.
•Provision of written informed consent by the participant or legally authorized representative.

•Acute illness, musculoskeletal injury, or pain interfering with the ability to perform the intervention exercises.
•Uncompensated visual or hearing impairments that limit participation.
•Disruptive behavior or other conditions that significantly hinder participation in the rehabilitation program.
•Active epilepsy or any medical contraindication to physical exercise.
•Botulinum toxin treatment in the upper limb within the previous 6 months.