Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Amgen
Age
18–75
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
1. Adults 18 to 75 years of age, male or female.
2. Body mass index ≥ 22 kg/m\^2 at screening.
3. For participants with normal hepatic function:
* In good health with no clinically significant findings from medical history, physical exam, electrocardiogram (ECG), vital signs, or laboratory tests.
* Systolic blood pressure (BP) 90-150 mmHg and diastolic BP 50-100 mmHg; pulse 40-110 bpm.
* Stable body weight (\< 5 kg change) and no recent dietary modifications within 3 months.
4. For participants with hepatic impairment:
* Documented Child-Pugh Class A (mild), B (moderate), or C (severe) hepatic impairment.
* Systolic BP ≤ 170 mmHg and diastolic BP ≤ 100 mmHg.
5. Willing to use reliable contraception (if of childbearing potential) or practice abstinence through 16 weeks after dosing.
You may not be if
1. Any unstable medical condition (e.g., recent hospitalization or major surgery).
2. History of acute or chronic pancreatitis within 1 year or lipase/amylase \> 2× ULN at screening.
3. Endocrine disorder that can cause obesity (e.g., Cushing's syndrome).
4. Significant cardiac conditions (e.g., clinically meaningful arrhythmias, 2nd/3rd-degree AV block, QT Interval Corrected Using Fridericia's Formula (QTcF) \>450 msec men / \>470 msec women for normal hepatic group; \> 490 msec men / \> 500 msec women for hepatic impairment).
