Comparison of Combination of Itraconazole and Isotretinoin Versus Itraconazole Alone in the Treatment of Resistant Trichophyton Infection

Exclusion Criteria

• •Negative potassium hydroxide microscopy and no culture evidence of Trichophyton infection at baseline
• •Infection caused by non-Trichophyton dermatophytes on culture, or no growth on culture where culture is used for confirmation
• •Use of additional systemic antifungal therapy during the treatment period (not permitted by protocol)
• •Use of systemic retinoids other than study-assigned isotretinoin during the treatment period (not permitted by protocol)
• •Pregnancy at baseline in women of childbearing potential, or inability or unwillingness to follow strict pregnancy avoidance requirements during and after isotretinoin therapy
• •Any contraindication to itraconazole or isotretinoin, including known hypersensitivity to either drug
• •Clinically significant baseline liver dysfunction or abnormal liver function tests considered unsafe for systemic itraconazole and or isotretinoin use