Pulse Oximeter Accuracy During Stable Hypoxia Plateaus

Exclusion Criteria

• •1. The subject has a BMI above 40
• •2. The subject has blood pressure above 160 systolic or 95 diastolic
• •3. The subject has a known history of heart disease, lung disease, kidney or liver disease.
• •4. Diagnosis of asthma, sleep apnea, or use of CPAP.
• •5. Subject has diabetes.
• •6. Subject has a clotting disorder.
• •7. The subject has a hemoglobinopathy or history of anemia, per subject report or the first blood sample, that in the opinion of the investigator, would make them unsuitable for study participation. (COHb\<3%, MetHb\<2%, ctHb\>10 g/dL).
• •8. The subject has any other serious systemic illness.
• •9. The subject has smoked in the last 12 hours.
• •10. Any injury, deformity, or abnormality at the sensor sites that in the opinion of the investigators would interfere with the sensors working correctly.
• •11. The subject has a history of fainting or vasovagal response.
• •12. The subject has a history of sensitivity to local anesthesia.
• •13. The subject has a diagnosis of Raynaud's disease.
• •14. The subject has unacceptable collateral circulation based on exam by the investigator (Allen's test).
• •15. The subject is pregnant, lactating or trying to get pregnant.
• •16. Subjects who have uneven skin tones at the forehead or the sensor site.
• •17. The subject is unable or unwilling to provide informed consent or is unable or unwilling to comply with study procedures.
• •18. The subject has any other condition, which in the opinion of the investigators would make them unsuitable for the study.