Evaluation of Circulating Immune Response After Histosonics in Colorectal Cancer (ECHO-CRC)

Exclusion Criteria

• •Major surgical procedure or significant traumatic injury within 14 days prior to histotripsy.
• •* Therapy with an investigational drug within 14 days prior to histotripsy.
• •* Clinically significant cardiovascular or cerebrovascular disease, including:
• •* Myocardial infarction within 3 months prior to enrollment.
• •* Unstable angina.
• •* Congestive heart failure (New York Heart Association Classification Class \> II).
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• •* Cerebrovascular stroke with deficit within 3 months prior to enrollment.
• •* Active infection requiring systemic therapy within 14 days prior to histotripsy, unless deemed to be a chronic disease state by the study PI.
• •* Active pregnancy.
• •* Patients with active infections, autoimmune diseases requiring systemic immunosuppression, or other uncontrolled comorbidities that could interfere with study participation will be excluded.
• •* Severe cancer-associated cachexia that may interfere with systemic immune response, as assessed by the treating physician.
• •* Any ongoing medical illness or injury that would significantly impact tolerability of therapy, including but not limited to:
• •* Serious, non-healing or dehiscing wound, active ulcer, or untreated bone fracture.
• •* Clinical signs or symptoms of gastrointestinal obstruction or requirement for routine parenteral hydration, parenteral nutrition, or tube feeding.
• •* Any other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding that contraindicates histotripsy, may affect the interpretation of study results, or may render the patient at high risk for treatment complications.
• •* Anyone that is unable to consent due to cognitive, psychological or other reasons that impact their capacity.
• •* Deemed to be inappropriate for enrollment by the study PI.