Clareo Health | A Multicenter, Prospective, Randomized, Controlled Study of Decitabine in Combination With R-CHOP for Initial Treatment of EBV+ Diffuse Large B-cell Lymphoma
A Multicenter, Prospective, Randomized, Controlled Study of Decitabine in Combination With R-CHOP for Initial Treatment of EBV+ Diffuse Large B-cell Lymphoma
Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Second Affiliated Hospital of Nanchang University
Age
18–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Initial treatment of diffuse large B-cell lymphoma (DLBCL) confirmed by tumor histopathology with at least one lesion on either axis More than 1.5 cm, sufficient specimens for second-generation sequencing or single-cell sequencing;
2. Age \> 18 years old, \< 80 years old, gender unlimited;
3. EBER+ or peripheral blood EBV-DNA of pathological specimen was greater than 103copy/ml;
4. Patients judged by the investigator to have a life expectancy of at least 6 months;
5. The patient or his legal representative must provide written informed consent prior to any research special examination or procedure.
6. Signed written informed consent before screening.
You may not be if
1. Have previously received systemic or local treatment including chemotherapy;
2. Previously received autologous stem cell transplantation;
3. Previous history of other malignant tumors, except skin basal cell carcinoma and cervical carcinoma in situ;
4. Accompanied by uncontrolled cardiovascular and cerebrovascular diseases, coagulation disorders, connective tissue diseases and serious infectious diseases;
5. Lymphoma involves the central nervous system;
6. Primary mediastinal large B-cell lymphoma;
7. Left ventricular ejection fraction \< 50%;
8. Laboratory test values at the time of screening: (unless due to lymphoma);
1. Neutrophils \< 1.5 x 109/L;
2. Platelet \< 75 x 109/L;
3. ALT or AST were 2 times higher than the upper limit of normal, AKP and bilirubin were 1.5 times higher than the upper limit of normal;
4. creatinine levels higher than 1.5 times the upper limit of normal;
9. Patients with mental illness or other patients known or suspected to be unable to fully comply with the study protocol;
10. Pregnant or lactating women;
12. Other concurrent and uncontrolled medical conditions that the investigator believes will affect the patient's participation in the study.
