Efficacy and Safety of Xeligekimab in the Treatment of Non-Radiographic Axial Spondyloarthritis

Exclusion Criteria

• •Patients with radiographic evidence of sacroiliitis, bilateral ≥grade 2 or unilateral ≥grade 3;
• •Presence of other active inflammations besides axial spondyloarthritis (e.g., active inflammatory bowel disease \[IBD\] or uveitis);
• •Chest X-ray suggesting active infection or malignant lesions;
• •Active systemic infection within 2 weeks prior to enrollment;
• •Known tuberculosis, HIV, hepatitis B, or hepatitis C infection at screening;
• •History of lymphoproliferative disease, any history of malignancy (within the past 5 years);
• •Subjects with unstable cardiovascular disease;
• •Patients taking potent opioid analgesics;
• •Pregnant or lactating women.