Norwegian Spontaneous Coronary Artery Dissection Study

Background: SCAD has emerged as an important cause of myocardial infarction, especially among women under 60 years of age, and is a leading cause of pregnancy-related myocardial infarction. Despite increased awareness over the past two decades, SCAD remains under-recognized, and management varies widely because of limited evidence. Key gaps persist in understanding SCAD etiology, precipitating factors, optimal diagnostic follow-up (including the role of CTA), and the incidence of complications. Objectives: Primary objectives: Determine the incidence and types of complications and major adverse cardiac events (MACE) within the first year after SCAD. Secondary objectives: Evaluate the diagnostic and follow-up utility of coronary CTA. Methods: * Multicenter prospective observational cohort study. * Enrollment period: 2025-2035. * Study population: Adults (≥18 years) hospitalized with angiographically or imaging-confirmed SCAD at participating hospitals in Norway. * Follow-up duration: 52 weeks per participant. Study visits and procedures: 1. Week 1: Acute hospitalization with CT index and blood samples 2. Week 8: CT control 3. Week 12: Comprehensive physical examination with cardiac exams, blood samples, CPET 4. Week 52: Final follow-up phone call to assess clinical events Endpoints includes major cardiac events (MACE), CTA findings and quality of life.