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Not Yet RecruitingPhase 2NCT07310407

Rutin and Vitamin C in Patients With Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD)

evaluate the combined effects of Rutin and Vitamin C versus Vitamin C alone on selected oxidative stress markers, inflammation, hepatic steatosis regression, and associated metabolic parameters in pat...

Lead sponsor: Ain Shams University•1 locations•View source on ClinicalTrials.gov

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Contacts

Shaimaa s Bashoaib, master

CONTACT

+201091316484 [email protected]

Sarah M Fahmy, Asso Prof

CONTACT

+201127666522 [email protected]

Sponsors

Lead Sponsor

Ain Shams University

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a common liver disorder with risks of progression to fibrosis, cirrhosis, and hepatocellular carcinoma. Its global prevalence is high, driven by oxidative stress and impaired antioxidant defenses, while no approved pharmacological treatments currently exist. Nutritional agents such as vitamin C and rutin show promise in improving liver function and reducing oxidative damage. This study will evaluate their combined effects in addressing MASLD's multifactorial pathology.

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Confirmed diagnosis of Metabolic-Associated Steatotic Liver Disease (MASLD).

Exclusion Criteria

•HCV infection.
•HBV infection.
•Patients with a history of significant alcohol consumption.
•Autoimmune hepatitis.
•Celiac disease (CD).
•Wilson's disease (WD).
•Haemochromatosis.
•Drugs: Tamoxifen, Valproic acid, Amiodarone, Methotrexate, steroids and immunosuppressive agents, oral contraceptive pills, or drugs that can affect liver profile.
•Hypo or hyper thyroidism.
•Bypass surgeries.
•TPN (Total Parenteral Nutrition).
•Pregnant individuals or patients planning to become pregnant.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: December 30, 2025Terms

Trial snapshot

StatusNOT_YET_RECRUITING

PhasePHASE2

Enrollment120

Start dateJan 2026

Last updatedDec 30, 2025

Condition

Locations shown

National Hepatology and Tropical Medicine Research Institute (NHTMRI)

Cairo

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 30, 2025Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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