KetoBrain: Brain Energy Metabolism in Schizophrenia

Exclusion Criteria

• •1. Any coercive measure including patients in forensic psychiatry
• •2. In a clinical condition where the treating clinician evaluates that the patient is not able to attend the research study.
• •3. Previous use of AP at an antipsychotic dose (except for Risperidone ≤0.5 mg, Abilify ≤2.5 mg, Seroquel ≤50 mg or Zyprexa ≤2.5 mg) for more than 2 continuous weeks in the past year and/or 6 weeks over a lifetime
• •4. Use of an antipsychotic in the last 3 months before inclusion at a dose greater than:
• •4.1 Seroquel/Quetiapine 50 mg 4.2 Risperdal/Risperidone 0.5 mg
• •5. Comorbidity: Borderline intelligence or intellectual disability, autism spectrum disorder, decompensated substance use disorder, psychosis induced by a medical condition or psychosis induced by medication or drug use.
• •6. Pregnancy, childbirth within the past 6 months, or breastfeeding. Female participants should use an effective contraception.
• •7. Contraindications to MRI (metal, severe claustrophobia).
• •8. Acute suicidal thoughts (e.g., resulting in hospitalization)
• •9. Diabetes mellitus type 1. History of severe head trauma, stroke, chemotherapy or brain surgery. Hypo- or hyperthyroidism. Epilepsy. Systemic glucocorticoid hormone treatment.
• •10. Other conditions interfering with participation according to the qualified physician's judgment.
• •1. Previous use of an antipsychotic dose (except for Risperidone ≤0.5 mg, Abilify ≤2.5 mg, Seroquel ≤50 mg or Zyprexa ≤2.5 mg) for more than 2 continuous weeks in the past year and/or 6 weeks over a lifetime
• •2. Use of AP in the last 3 months before inclusion at a dose greater than:
• •1. Seroquel/Quetiapine 50 mg
• •2. Risperdal/Risperidone 0.5 mg
• •3. Pregnancy, childbirth within the past 6 months, or breastfeeding. Female participants should use an effective contraception.
• •4. Contraindications to MRI (metal, severe claustrophobia).
• •5. Diabetes mellitus type 1. History of severe head trauma, stroke, chemotherapy or brain surgery. Hypo- or hyperthyroidism. Epilepsy. Systemic glucocorticoid hormone treatment.
• •6. Other conditions interfering with participation according to the qualified physician's judgment.