Anti-CCR9 CAR T Cells for T Cell Leukaemia/Lymphoma

Exclusion Criteria

• •ECOG performance score \>2 (patients aged ≥10 years old) OR Lanksy score ≤50% (patients aged \<10 years old)
• •Stem Cell Transplant patients only: active significant acute GvHD or moderate/severe chronic GvHD requiring immunosuppressive therapy and/or systemic steroids
• •Active CNS involvement of disease
• •Active hepatitis B, C or HIV infection
• •Oxygen saturation ≤90% on air
• •Bilirubin \>3 x upper limit of normal
• •GFR \<30 ml/min
• •Cardiac dysfunction
• •Patients receiving corticosteroids at a supraphysiological dose that cannot be discontinued
• •Known allergy to any component of the ATIMP
• •Any contraindications to lymphodepletion or to the use of cyclophosphamide or fludarabine as per local SmPC
• •Women who are pregnant or breastfeeding
• •Life expectancy \<3 months
• •Fulminant or rapidly progressive disease