Effect of Antifungals on the Intestinal Microbiome - a Randomized, Controlled, Proof-of-concept Trial

Exclusion Criteria

• •Major illness in the past 3 months, or significant chronic medical illness deemed unfavorable for enrollment
• •Past or current gastrointestinal disease that may influence the gut microbiota (including inflammatory bowel disease or medication-treated irritable bowel syndrome)
• •History of immunodeficiency
• •History of malignancy
• •Alcohol intake \>3 units/day on average
• •Known allergy to antifungal drugs
• •Use of antibiotics (except topical) within the past 3 months
• •Use of antifungals (except topical) within the past 3 months
• •Planned prolonged travel (\>4 weeks) to tropical countries during the study period
• •Receipt of an investigational product within 3 months prior to study day 0
• •Use of prescription or non-prescription drugs, herbal or dietary supplements within 3 months (unless deemed safe by investigator)
• •Difficulty with blood donation or poor venous access in either arm
• •Donation of \>500 mL of blood in the past 3 months
• •Any other condition or circumstance that, in the investigator's opinion, could be harmful to the subject or compromise data interpretation