Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial

Exclusion Criteria

• •History of coronary artery bypass graft (CABG).
• •Moderate to severe renal dysfunction.
• •Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) \> 3 x upper limit of normal (ULN), or total bilirubin (TBL) \> 2 x ULN during screening.
• •History of hemorrhagic stroke.
• •History of major bleeding disorder.
• •Planned cardiac surgery or arterial revascularization.
• •Severe heart failure.
• •Current, recent, or planned lipoprotein apheresis.
• •Previously received ribonucleic acid therapy specifically targeting Lp(a).