tAN for Substance Use Disorder

Inclusion Criteria

• •1. Male or female (evenly recruited) aged 18-64 years old
• •2. Meeting DSM-5 criteria of moderate or above AUD at screening using the structured clinical interview for DSM-5 (SCID-5)
• •3. Demonstration of at least moderate risk of alcohol use at screening using the WHO-ASSIST
• •4. Demonstration of high risk for moderate to severe alcohol withdrawal syndrome (Prediction of Alcohol Withdrawal Severity Scale \[PAWSS\] \> 4 at admission)
• •5. Demonstration of severe withdrawal symptoms (Clinical Institute Withdrawal Assessment of Alcohol Scale, Revised \[CIWA-Ar\] \> 15 at screening)
• •6. Positive urine test for alcohol at screening
• •7. Be able to provide written informed consent
• •8. Female subjects must be non-nursing and not pregnant
• •9. Meet the MRI safety screening form provided by the Center for Advanced MR Imaging (CAMRI) at BCM.