Pan- NET, ENETS/AJCC stage 4 determined by CT or PET/CT
Primary tumour or metastases confirmed as Pancreatic NET GI-WHO grade 1-2 pan-NET by histology or cytology
Age ≥ 18 years
Written informed consent obtained
You may not be if
Subject not fit for surgery due to comorbidity or advanced age (reason to be specified)
Risk of surgery deemed too high by MDT or Surgeon (reason to be specified)
Previous surgery for pan-NET.
Hormonal symptoms caused by a functional pan-NET, not controllable by medical therapy, indicating debulking surgery.
Previously included in the current study.
Pregnancy
The study subject does not fit into either STRATA: a) STRATUM 1: Less than 70% of the total tumour volume can be debulked, b) STRATUM 2: no FDG-PET avid disease is observed OR all (100%) FDG-PET avid tumour is not resectable.
Other reason in the opinion of the Principal Investigator (reason to be specified).
Clareo Health | Pancreatic Neuroendocrine Tumour - Optimal Surgical Debulking or Not
